Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles.

نویسندگان

  • Cleiton da Silva Oliveira
  • Bruna Teles Soares Beserra
  • Raphael Salles Granato Cunha
  • Ana Gabriela Estevam Brito
  • Rafaella Cristina Dimbarre de Miranda
  • Lúcia Andréia Zanette Ramos Zeni
  • Everson Araújo Nunes
  • Erasmo Benicio Santos de Moraes Trindade
چکیده

OBJECTIVE To evaluate the behavior of acute phase proteins and lipid profile in patients undergoing Roux-en-Y gastric bypass. METHODS We conducted a prospective study, consisting of three moments: M1 - preoperative (24 hours before surgery); M2 - 30 days after surgery; and M3 - 180 days after surgery. We carried measured height and BMI, as well as determined the concentrations of acute phase proteins (C-reactive protein (CRP), albumin and Alpha-1-acid glycoprotein) and total cholesterol, LDL-c, HDL-c and triacylglycerol. RESULTS participants comprised 25 individuals, with a mean age of 39.28 ± 8.07, 72% female. At all times of the study there was statistically significant difference as for weight loss and BMI. We found a significant decrease in CRP concentrations between the moments M1 and M3 (p = 0.041) and between M2 and M3 (p = 0.018). There was decrease in Alpha-1-GA concentrations between M1 and M2 (p = 0.023) and between M1 and M3 (p = 0.028). The albumin values increased, but did not differ between times. Total cholesterol and triacylglycerol decreased significantly ay all times. LDL-c concentrations decreased and differed between M1 and M2 (p = 0.001) and between M1 and M3 (p = 0.001). HDL-c values increased, however only differing between M1 and M2 (p = 0.050). CONCLUSION Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.

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عنوان ژورنال:
  • Revista do Colegio Brasileiro de Cirurgioes

دوره 42 5  شماره 

صفحات  -

تاریخ انتشار 2015